The Modern Vital Podcast

Unraveling the Paradox: When Detoxification Turns Toxic

June 21, 2023 Ben Reebs Season 1 Episode 17
The Modern Vital Podcast
Unraveling the Paradox: When Detoxification Turns Toxic
Show Notes

In this episode of The Modern Vital Podcast, the topic of detoxification and its potential to worsen symptoms is explored. The intricate connection between the protein metallothionines and the mineral zinc is discussed, shedding light on how these proteins can mitigate damage from heavy metals such as cadmium and mercury, but potentially trigger a zinc deficiency in the process. It's explained how these proteins might bind to heavy metals and discard zinc, subsequently leading to high levels of zinc appearing in blood or hair tests. This reveals a paradox where high blood levels of zinc could indicate a cellular deficiency, underlining the importance of working with an expert practitioner.

In the following segment, Dr. Reebs dives into the three phases of detoxification within the body, predominantly occurring in the liver. The process starts with Phase I, where fat-soluble toxins are transformed to become more water-soluble through the actions of the cytochrome P450 enzymes. During this phase, vital nutrients like B vitamins and antioxidants are needed to facilitate the process and combat oxidative stress. Paradoxically, detoxification can lead to an increase in oxidative stress, hence the need for antioxidants like vitamins C and E, selenium, and glutathione. It is also noted that minerals like zinc, magnesium, and iron play an essential role in detoxification pathways.

Finally, Phase II of detoxification is explored, where the processed toxins from Phase I undergo further modification, making them even more water-soluble and ready for elimination from the body. This process involves enzymes and multiple molecules, including glutathione, glucuronic acid, sulfate, methyl groups, and acetyl groups. The host highlights the importance of amino acids and antioxidants in this phase, with a special mention of sulfur-containing compounds found in cruciferous vegetables, onions, and garlic. It's warned that detoxification without proper functioning of the organs of elimination can make individuals sick, emphasizing the need for expert supervision during such processes.

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